Target

Caspase-6 SBDD

Halting the Inflammation Process

• Activated in human fibrotic conditions and NASH
• Inhibitors are efficacious in HFD mouse in vivo NASH model
• Robust BC and cell assays
• Inhibitors (IC50 = 1-10 nM) of active and inactive forms
  

  Soluble	Low CYP liability
  Permeable	Low hERG liability
  Metabolically stable	Selective

• Protein crystal structures solved for both forms
• SBDD enabled
• Allosteric inhibition observed
• Implicated in neurodegeneration