Target

Caspase-1

A Central Regulator Beyond NLRP3

  • Inhibits key inflammasome pathways
  • Activation of caspase-1 increases in patients and animal models of NLRP3-driven diseases
  • Caspase-1 genetic or pharmacological inhibition protected from NLRP3-induced inflammation
  • Also indicated in neuroinflammation: MS and AD
  • Reversible covalent approach based on SBDD