Target
Caspase-1
A Central Regulator Beyond NLRP3
- Inhibits key inflammasome pathways
- Activation of caspase-1 increases in patients and animal models of NLRP3-driven diseases
- Caspase-1 genetic or pharmacological inhibition protected from NLRP3-induced inflammation
- Also indicated in neuroinflammation: MS and AD
- Reversible covalent approach based on SBDD
